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Xiaoyu Chen BSc DPhil MRes

DPhil Candidate

TEL: 447737359687
COLLEGE: St Edmund Hall

Biography

Mr Jack Xiaoyu Chen completed his previous degree from Imperial College London and University College London.

Research Interests

Research interests include:
1. Directed evolution of regulatory protein and its application in constructing whole-cell biosensor
2. Machine learning approach in constructing synthetic bio-parts
3. Multiplex signal integration and decision making using the synthetic cellular network

Current Projects

Jack's PhD focuses on developing artificial cells (miniSimCells) with multiply small molecule biosensors for medical applications. His research projects were:

1) Development of an aspirin inducible gene circuits based on SalR regulatory circuit from Acinotebacter ADP1.
2) Development of ultrasensitive DNA damage response circuit from Vibrio natrigens.
3) Development of nitric oxide sensor from probiotics E. coli Nissle 1917
4) Characterisation and high-throughput extraction of chromosome free minicells.

Publications

Chen, J.X., Lim, B., Steel, H., Song, Y., Ji, M., and Huang, W.E. (2021) Redesign of ultrasensitive and robust RecA gene circuit to sense DNA damage. Microb Biotechnol 1751-7915.13767.

Chen, J.X., Steel,H., Wu,Y.H., Wang,Y., Xu,J., Rampley,C.P.N., Thompson,I.P., Papachristodoulou,A. and Huang,W.E. (2019) Development of aspirin inducible biosensors in Escherichia coli and SimCells. Appl. Environ. Microbiol., 10.1128/AEM.02959-18.

Song,Y., Rampley,C.P.N., Chen,J.X., Du,F., Thompson,I.P. and Huang,W.E. (2019) Application of Bacterial Whole-Cell Biosensors in Health BT - Handbook of Cell Biosensors. In Thouand,G. (ed). Springer International Publishing, Cham, pp. 1–17.