Skip to main content
Menu

International Brain Mechanics and Trauma Lab

Representative fluorescence micrograph showing differentiated F11 cells after 5 days in culture. Nuclei were labelled with DAPI ( blue) and Beta-III-tubulin immunoreactivity (green) was use to detect neurites. [Céline Kayal, Oxford]

Nanostructured, biocompatible scaffold to support 3D cell cultures with controled mechanical properties [Sonia Contera, Oxford]

MEG data visualization and navigation tool: Synchronization biomarkers of MCI patients [Antonio Gracia, UPM]

High-detailed synapse reconstruction: Electronic microscopy image segmentation by ESPINA software and rendered by GMRV [Marcos Garcia / Angel Rodriguez [URJC/UPM, Cajal Blue Brain]

Numerical model of a neuron under mechanical loading [Antoine Jerusalem, Oxford]

Neurites from SH-SY5Y neurons penetrate through an Isopore membrane [Hua Ye, Oxford]

Bundles of axons in porcine brain: 3,500x magnification using scanning electron microscopy [Rashid, Destrade and Gilchrist, Galway/Dublin]

Representative fluorescence micrograph showing differentiated F11 cells after 5 days in culture. Nuclei were labelled with DAPI ( blue) and Beta-III-tubulin immunoreactivity (green) was use to detect neurites. [Céline Kayal, Oxford]

The International Brain Mechanics and Trauma Lab (IBMTL)

The lab is an international initiative that was created in 2013. It involves the collaboration of 41 academics and clinicians, across 25 main institutions.

All members of the IBMTL are heavily involved in collaborative projects related directly to brain mechanics and trauma. The interaction between experts, from such a wide range of disciplines, is motivated by the need for multidisciplinary expertise to study the relationship between brain cell/tissue mechanics and brain functions/diseases/trauma:

  • Biology: stem cells, tissue engineering, physiopathology
  • Computing: supercomputing, neuroinformatics, image processing, big data analytics
  • Engineering: materials engineering, biomechanics, computational mechanics of materials, mechanobiology, systems engineering
  • Mathematics: mathematical modelling, computational statistics, continuum mechanics, data mining
  • Medical/Clinical: neurology, neuropathology, neuroimaging, veterinary medicine, neurosurgery, psychiatry
  • Neuroscience: translational neuroscience, functional connectivity and brain network architecture, brain plasticity computational modelling
  • Physics: nanoscience, cells/tissues nanomechanics, cell rheology, shockwave/ultrasound physics, biophysics

The collaboration is centred around the complementary collaboration of experts, from different disciplines, focussed on the study of the brain cell and tissue mechanics, and its relation with brain functions, diseases or trauma.