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Bob Carlisle Associate Professor

Professor

Robert Carlisle BSc DPhil MSc

Associate Professor

Director of MSc in Nanotechnology for Medicine and Healthcare

Associate Director of Synthetic Biology CDT

Biography

Robert Carlisle is an Associate Professor in Biomedical Engineering. After completing a BSc in Biochemistry, an MSc in Toxicology and a Ph.D in Gene Delivery at Birmingham University, he worked for 8 years within the Department of Clinical Pharmacology and the Department of Oncology at the University of Oxford. In 2012 he became a member of the Engineering Science Faculty.

The majority of Bob’s work has been concerned with achieving systemic delivery of anti-cancer agents for the treatment of metastatic cancer. This has included the development and testing of novel nano-scale non-viral and viral gene delivery systems and liposomal agents for the delivery of conventional chemotherapeutics.

Research within his labs covers the full scope of therapeutic design, formulation and testing with emphasis on how the specificity and efficacy of therapy can be improved. He is the Director of the MSc in Nanotechnology for Medicine and Healthcare and was Associate Director of the Synthetic Biology CDT (2015-2022).

Key Papers

Professor Carlisle is the recipient of the CRS Jorge Heller JCR Outstanding Paper Award 2016, for his paper Increasing the Density of Nanomedicines Improves Their Ultrasound-mediated Delivery to Tumours.

He is also one of the authors of the 2018 paper Safety and feasibility of ultrasound-triggered targeted drug delivery of doxorubicin from thermosensitive liposomes in liver tumours (TARDOX): a single-centre, open-label, phase 1 trial This detailed the results of a milestone study into the safety and feasibility of ultrasound devices used to enhance the delivery and distribution of anticancer drugs.

 

Most Recent Publications

The Oxford Needle Experience (ONE) scale: a UK-based and US-based online mixed-methods psychometric development and validation study of an instrument to assess needle fear, attitudes and expectations in the general public

The Oxford Needle Experience (ONE) scale: a UK-based and US-based online mixed-methods psychometric development and validation study of an instrument to assess needle fear, attitudes and expectations in the general public

Altmetric score is

Sonosensitive cavitation nuclei-a customisable platform technology for enhanced therapeutic delivery

Sonosensitive cavitation nuclei-a customisable platform technology for enhanced therapeutic delivery

Altmetric score is

HPB P26 Ex vivo normothermic perfusion of liver, kidney and spleen to predict human pharmacokinetics and assess drug delivery

HPB P26 Ex vivo normothermic perfusion of liver, kidney and spleen to predict human pharmacokinetics and assess drug delivery

Altmetric score is

Cavitation-mediated transcutaneous delivery of protein and nucleotide-based antigen for rapid high-level immune responses

Cavitation-mediated transcutaneous delivery of protein and nucleotide-based antigen for rapid high-level immune responses

Altmetric score is

Clinical trial protocol for PanDox: a phase I study of targeted chemotherapy delivery to non-resectable primary pancreatic tumours using thermosensitive liposomal doxorubicin (ThermoDox®) and focused ultrasound

Clinical trial protocol for PanDox: a phase I study of targeted chemotherapy delivery to non-resectable primary pancreatic tumours using thermosensitive liposomal doxorubicin (ThermoDox®) and focused ultrasound

Altmetric score is
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Research Interests

  • Design, formulation and testing of novel drug carriers
  • Improved understanding of tumour biology
  • Application of external stimuli for improved drug delivery to tumours
  • Transdermal delivery of drugs and vaccines
  • Clinical trials of device + drug combinations
  • Clinical and commercial translation of healthcare technologies

Research Team

Ms Matilde Maardalen - DPhil Student

Current Projects

OXCD3

Combining the best drug formulation and carrier systems with the best most targeted external stimuli.

Transdermavax

Use of formulation and external stimuli to drive vaccines and drugs into or across the skin.

Theroximmune

Combining external stimuli with immunotherapy for solid tumour treatment

Beyond Antibiotics

Addressing antimicrobial resistance

Most Recent Publications

The Oxford Needle Experience (ONE) scale: a UK-based and US-based online mixed-methods psychometric development and validation study of an instrument to assess needle fear, attitudes and expectations in the general public

The Oxford Needle Experience (ONE) scale: a UK-based and US-based online mixed-methods psychometric development and validation study of an instrument to assess needle fear, attitudes and expectations in the general public

Altmetric score is

Sonosensitive cavitation nuclei-a customisable platform technology for enhanced therapeutic delivery

Sonosensitive cavitation nuclei-a customisable platform technology for enhanced therapeutic delivery

Altmetric score is

HPB P26 Ex vivo normothermic perfusion of liver, kidney and spleen to predict human pharmacokinetics and assess drug delivery

HPB P26 Ex vivo normothermic perfusion of liver, kidney and spleen to predict human pharmacokinetics and assess drug delivery

Altmetric score is

Cavitation-mediated transcutaneous delivery of protein and nucleotide-based antigen for rapid high-level immune responses

Cavitation-mediated transcutaneous delivery of protein and nucleotide-based antigen for rapid high-level immune responses

Altmetric score is

Clinical trial protocol for PanDox: a phase I study of targeted chemotherapy delivery to non-resectable primary pancreatic tumours using thermosensitive liposomal doxorubicin (ThermoDox®) and focused ultrasound

Clinical trial protocol for PanDox: a phase I study of targeted chemotherapy delivery to non-resectable primary pancreatic tumours using thermosensitive liposomal doxorubicin (ThermoDox®) and focused ultrasound

Altmetric score is
View all

DPhil Opportunities

I am interested in supervising DPhil students working in vaccine formulation and delivery or solid tumour therapy.

Most Recent Publications

The Oxford Needle Experience (ONE) scale: a UK-based and US-based online mixed-methods psychometric development and validation study of an instrument to assess needle fear, attitudes and expectations in the general public

The Oxford Needle Experience (ONE) scale: a UK-based and US-based online mixed-methods psychometric development and validation study of an instrument to assess needle fear, attitudes and expectations in the general public

Altmetric score is

Sonosensitive cavitation nuclei-a customisable platform technology for enhanced therapeutic delivery

Sonosensitive cavitation nuclei-a customisable platform technology for enhanced therapeutic delivery

Altmetric score is

HPB P26 Ex vivo normothermic perfusion of liver, kidney and spleen to predict human pharmacokinetics and assess drug delivery

HPB P26 Ex vivo normothermic perfusion of liver, kidney and spleen to predict human pharmacokinetics and assess drug delivery

Altmetric score is

Cavitation-mediated transcutaneous delivery of protein and nucleotide-based antigen for rapid high-level immune responses

Cavitation-mediated transcutaneous delivery of protein and nucleotide-based antigen for rapid high-level immune responses

Altmetric score is

Clinical trial protocol for PanDox: a phase I study of targeted chemotherapy delivery to non-resectable primary pancreatic tumours using thermosensitive liposomal doxorubicin (ThermoDox®) and focused ultrasound

Clinical trial protocol for PanDox: a phase I study of targeted chemotherapy delivery to non-resectable primary pancreatic tumours using thermosensitive liposomal doxorubicin (ThermoDox®) and focused ultrasound

Altmetric score is
View all