Showing 50 publications by Tim Denison
Heterogeneity in deep brain stimulation gamma enhancement explained by bifurcations in neural dynamics
Biber SW, Sermon JJ, Kaplan J, Busch JL, Kühn AA et al. (2026)
A cardiac pulse signal affects local field potentials recorded from deep brain stimulation electrodes across clinical targets
Tourigny KR, Piper RJ, Tisdall M, Neumann W-J, Green AL et al. (2026)
Modulation of motor cortical theta and gamma oscillations using phase-targeted, closed-loop optogenetic stimulation of local excitatory and inhibitory neurons.
Myatt JL, Toth R, Denison T, Grennan I, McNamara CG et al. (2026), Brain Stimulation, 19(2), 103034
BibTeX
@article{modulationofmot-2026/1,
title={Modulation of motor cortical theta and gamma oscillations using phase-targeted, closed-loop optogenetic stimulation of local excitatory and inhibitory neurons.},
author={Myatt JL, Toth R, Denison T, Grennan I, McNamara CG et al.},
journal={Brain Stimulation},
volume={19},
number={103034},
pages={103034},
publisher={Elsevier},
year = "2026"
}
Post-Ictal Sleep Changes in Human Focal Epilepsy.
Kremen V, Sladky V, Gerla V, Cao Y, Mivalt F et al. (2026), Journal of Neuroscience, e0303252026
Pilot Trial of the <i>Picostim® Deep Brain Stimulation System</i> for Children With Epilepsy: A Prospective, Open-Label Medical Device Study of a System Optimised for Paediatric Neuromodulation
Piper RJ, Fleming JE, Van Rheede JJ, Marks V, Landin K et al. (2026)
BibTeX
@misc{pilottrialofthe-2026/,
title={Pilot Trial of the <i>Picostim® Deep Brain Stimulation System</i> for Children With Epilepsy: A Prospective, Open-Label Medical Device Study of a System Optimised for Paediatric Neuromodulation},
author={Piper RJ, Fleming JE, Van Rheede JJ, Marks V, Landin K et al.},
year = "2026"
}
Letter to the Editor: Precision-guided multi-site insular deep brain stimulation for refractory neuropathic pain
Segerdahl AR, Deli A, Raghu ALB, Crockett R, Denison T et al. (2025), Brain Stimulation, 102999
BibTeX
@article{lettertotheedit-2025/12,
title={Letter to the Editor: Precision-guided multi-site insular deep brain stimulation for refractory neuropathic pain},
author={Segerdahl AR, Deli A, Raghu ALB, Crockett R, Denison T et al.},
journal={Brain Stimulation},
pages={102999},
publisher={Elsevier},
year = "2025"
}
Sleep stage can be selectively modulated through targeted deep brain stimulation of brainstem circuits
Deli A, Duchet B, He S, Huang Y, Martin S et al. (2025), Brain Stimulation, 18(6), 1931-1934
BibTeX
@article{sleepstagecanbe-2025/11,
title={Sleep stage can be selectively modulated through targeted deep brain stimulation of brainstem circuits},
author={Deli A, Duchet B, He S, Huang Y, Martin S et al.},
journal={Brain Stimulation},
volume={18},
pages={1931-1934},
publisher={Elsevier},
year = "2025"
}
Adaptive neuromodulation dialogues: navigating current challenges and emerging innovations in neuromodulation system development.
Lampert F, Baker MR, Jensen MA, Ayyoubi AH, Bentler C et al. (2025), Journal of Neural Engineering
BibTeX
@article{adaptiveneuromo-2025/11,
title={Adaptive neuromodulation dialogues: navigating current challenges and emerging innovations in neuromodulation system development.},
author={Lampert F, Baker MR, Jensen MA, Ayyoubi AH, Bentler C et al.},
journal={Journal of Neural Engineering},
publisher={IOP Publishing},
year = "2025"
}
A template for class III active implantable device research in the UK
Piper RJ, Landin K, Manfrin A, Patel S, Fleming J et al. (2025), Nature Reviews Bioengineering, 1-3
Prediction of Pathological Subthalamic Nucleus Beta Burst Occurrence in Parkinson's Disease
Abdi‐Sargezeh B, Shirani S, Sharma A, Liu T, Green A et al. (2025), Movement Disorders
Flexible and stable cycle-by-cycle phase-locked deep brain stimulation system targeting brain oscillations in the management of movement disorders
Guo X, Pogosyan A, Debarros J, He S, Wehmeyer L et al. (2025), Brain Stimulation, 18(5), 1705-1717
BibTeX
@article{flexibleandstab-2025/9,
title={Flexible and stable cycle-by-cycle phase-locked deep brain stimulation system targeting brain oscillations in the management of movement disorders},
author={Guo X, Pogosyan A, Debarros J, He S, Wehmeyer L et al.},
journal={Brain Stimulation},
volume={18},
pages={1705-1717},
publisher={Elsevier},
year = "2025"
}
Phasic and tonic pain serve distinct functions during adaptive behaviour
Tong S, Denison T, Hewitt D, Lee SW & Seymour B (2025)
Phasic and tonic pain serve distinct functions during adaptive behaviour
Tong S, Denison T, Hewitt D, Lee SW & Seymour B (2025)
Seizure forecasting by tracking cortical response to electrical stimulation
Laiou P, Kraljevic Z, Valentin A, Jewell S, Viana PF et al. (2025), Epilepsia: Official journal of the International League Against Epilepsy
BibTeX
@article{seizureforecast-2025/7,
title={Seizure forecasting by tracking cortical response to electrical stimulation},
author={Laiou P, Kraljevic Z, Valentin A, Jewell S, Viana PF et al.},
journal={Epilepsia: Official journal of the International League Against Epilepsy},
publisher={Wiley},
year = "2025"
}
Assessing Phase-Locked Repetitive Transcranial Magnetic Stimulation for Treatment of Parkinson’s and Essential Tremor
Sharma P, Vasaturo-Kolodner T, Mancini V, Shackle N, Wendt K et al. (2025), Brain Stimulation, 18(4), 1292-1293
BibTeX
@article{assessingphasel-2025/7,
title={Assessing Phase-Locked Repetitive Transcranial Magnetic Stimulation for Treatment of Parkinson’s and Essential Tremor},
author={Sharma P, Vasaturo-Kolodner T, Mancini V, Shackle N, Wendt K et al.},
journal={Brain Stimulation},
volume={18},
pages={1292-1293},
publisher={Elsevier},
year = "2025"
}
Modulating limbic circuits in temporal lobe epilepsy: impacts on seizures, memory, mood and sleep
Kremen V, Sladky V, Mivalt F, Gregg NM, Brinkmann BH et al. (2025), Brain Communications, 7(2)
BibTeX
@article{modulatinglimbi-2025/4,
title={Modulating limbic circuits in temporal lobe epilepsy: impacts on seizures, memory, mood and sleep},
author={Kremen V, Sladky V, Mivalt F, Gregg NM, Brinkmann BH et al.},
journal={Brain Communications},
volume={7},
number={fcaf106},
publisher={Oxford University Press},
year = "2025"
}
Augmenting rehabilitation robotics with spinal cord neuromodulation: A proof of concept.
Hankov N, Caban M, Demesmaeker R, Roulet M, Komi S et al. (2025), Science robotics, 10(100), eadn5564
Reducing inequalities through greater diversity in clinical trials – as important for medical devices as for drugs and therapeutics
Roope LSJ, Walsh J, Welland M, Samuel G, Johansen-Berg H et al. (2025), Contemporary Clinical Trials Communications, 101467
BibTeX
@article{reducinginequal-2025/3,
title={Reducing inequalities through greater diversity in clinical trials – as important for medical devices as for drugs and therapeutics},
author={Roope LSJ, Walsh J, Welland M, Samuel G, Johansen-Berg H et al.},
journal={Contemporary Clinical Trials Communications},
pages={101467},
publisher={Elsevier},
year = "2025"
}
Multi-level encoding of reward, effort and choice across the frontal cortex and basal ganglia during cost-benefit decision making
Harmson O, Grennan I, Perry B, Toth R, McNamara C et al. (2025), Cell Reports, 44(2)
BibTeX
@article{multilevelencod-2025/1,
title={Multi-level encoding of reward, effort and choice across the frontal cortex and basal ganglia during cost-benefit decision making},
author={Harmson O, Grennan I, Perry B, Toth R, McNamara C et al.},
journal={Cell Reports},
volume={44},
number={115209},
publisher={Cell Press},
year = "2025"
}
Modeling the determinants of attrition in a two-stage epilepsy prevalence survey in Nairobi using machine learning
Mwanga DM, Kipchirchir IC, Muhua GO, Newton CR, Kadengye DT et al. (2025), Global Epidemiology, 9, 100183
BibTeX
@article{modelingthedete-2025/1,
title={Modeling the determinants of attrition in a two-stage epilepsy prevalence survey in Nairobi using machine learning},
author={Mwanga DM, Kipchirchir IC, Muhua GO, Newton CR, Kadengye DT et al.},
journal={Global Epidemiology},
volume={9},
number={100183},
pages={100183},
publisher={Elsevier},
year = "2025"
}
On brain stimulation in epilepsy.
Trevelyan AJ, Marks VS, Graham RT, Denison T, Jackson A et al. (2025), Brain : a journal of neurology, awae385
An application-based taxonomy for brain-computer interfaces.
Robinson JT, Norman SL, Angle MR, Constandinou TG, Denison T et al. (2024), Nature biomedical engineering
Challenges and opportunities of acquiring cortical recordings for chronic adaptive deep brain stimulation.
Herron J, Kullmann A, Denison T, Goodman WK, Gunduz A et al. (2024), Nature biomedical engineering
A survey of few-shot learning for biomedical time series
Li C, Denison T & Zhu T (2024), IEEE Reviews in Biomedical Engineering, 18, 192-210
A digital dashboard for reporting mental, neurological and substance use disorders in Nairobi, Kenya: Implementing an open source data technology for improving data capture
Mwanga DM, Waruingi S, Manolova G, Wekesah FM, Kadengye DT et al. (2024), PLOS Digital Health, 3(11)
BibTeX
@article{adigitaldashboa-2024/11,
title={A digital dashboard for reporting mental, neurological and substance use disorders in Nairobi, Kenya: Implementing an open source data technology for improving data capture},
author={Mwanga DM, Waruingi S, Manolova G, Wekesah FM, Kadengye DT et al.},
journal={PLOS Digital Health},
volume={3},
number={e0000646},
publisher={Public Library of Science},
year = "2024"
}
Development and evaluation of a real-time phase-triggered stimulation algorithm for the CorTec Brain Interchange
Cho H, Benjaber M, Alexis Gkogkidis C, Buchheit M, Ruiz-Rodriguez JF et al. (2024), IEEE Transactions on Neural Systems and Rehabilitation Engineering, 32, 3625-3635
BibTeX
@article{developmentande-2024/9,
title={Development and evaluation of a real-time phase-triggered stimulation algorithm for the CorTec Brain Interchange},
author={Cho H, Benjaber M, Alexis Gkogkidis C, Buchheit M, Ruiz-Rodriguez JF et al.},
journal={IEEE Transactions on Neural Systems and Rehabilitation Engineering},
volume={32},
pages={3625-3635},
publisher={IEEE},
year = "2024"
}
Offline hippocampal reactivation during dentate spikes supports flexible memory
McHugh S, Lopes Dos Santos V, Castelli M, Gava G, Thompson S et al. (2024), Neuron, 112(22), p3768-3781.e8
BibTeX
@article{offlinehippocam-2024/9,
title={Offline hippocampal reactivation during dentate spikes supports flexible memory},
author={McHugh S, Lopes Dos Santos V, Castelli M, Gava G, Thompson S et al.},
journal={Neuron},
volume={112},
pages={p3768-3781.e8},
publisher={Cell Press},
year = "2024"
}
Pudendal nerve stimulation for treatment of lower urinary tract symptoms: A systematic review of safety, technical feasibility and clinical efficacy
Herroelen S, Knowles C, Kerrigan-Smith J, Noone T, Denison T et al. (2024), Continence, 11, 101685
BibTeX
@article{pudendalnervest-2024/9,
title={Pudendal nerve stimulation for treatment of lower urinary tract symptoms: A systematic review of safety, technical feasibility and clinical efficacy},
author={Herroelen S, Knowles C, Kerrigan-Smith J, Noone T, Denison T et al.},
journal={Continence},
volume={11},
pages={101685},
publisher={Elsevier},
year = "2024"
}
Attitudes and perceptions towards epilepsy in an onchocerciasis-endemic region of Tanzania: a mixed approach to determine the magnitude and driving factors
Mushi VP, Kidima W, Massawe IS, Magili PF, Bhwana D et al. (2024), BMC Public Health, 24(1)
BibTeX
@article{attitudesandper-2024/9,
title={Attitudes and perceptions towards epilepsy in an onchocerciasis-endemic region of Tanzania: a mixed approach to determine the magnitude and driving factors},
author={Mushi VP, Kidima W, Massawe IS, Magili PF, Bhwana D et al.},
journal={BMC Public Health},
volume={24},
number={2608},
publisher={BioMed Central},
year = "2024"
}
Longevity of a brain-computer interface for amyotrophic lateral sclerosis
Vansteensel MJ, Leinders S, Branco MP, Crone NE, Denison T et al. (2024), New England Journal of Medicine, 391(7), 619-626
BibTeX
@article{longevityofabra-2024/8,
title={Longevity of a brain-computer interface for amyotrophic lateral sclerosis},
author={Vansteensel MJ, Leinders S, Branco MP, Crone NE, Denison T et al.},
journal={New England Journal of Medicine},
volume={391},
pages={619-626},
publisher={Massachusetts Medical Society},
year = "2024"
}
Translation of neurotechnologies
Schalk G, Brunner P, Allison BZ, Soekadar SR, Guan C et al. (2024), Nature Reviews Bioengineering, 2(8), 637-652
The convergence of neuromodulation and brain–computer interfaces
Herron J, Kremen V, Simeral JD, Dawes H, Worrell GA et al. (2024), Nature Reviews Bioengineering, 2(8), 628-630
Challenges and opportunities for physiologically controlled therapy in neural systems
Marks VS, Piper RJ, Van Rheede JJ, Benjaber M, Green AL et al. (2024), IEEE Pulse, 15(2), 15-20
"EpilepSee" Glasses: A Wearable Seizure Prevention Device for Photosensitive Epilepsy.
Crooks G, Perks J, Gawne F, Ali H, Steel H et al. (2024), Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference, 2024, 1-4
Evoked resonant neural activity long-term dynamics can be reproduced by a computational model with vesicle depletion.
Sermon JJ, Wiest C, Tan H, Denison T & Duchet B (2024), Neurobiology of disease, 199, 106565
BibTeX
@article{evokedresonantn-2024/6,
title={Evoked resonant neural activity long-term dynamics can be reproduced by a computational model with vesicle depletion.},
author={Sermon JJ, Wiest C, Tan H, Denison T & Duchet B},
journal={Neurobiology of disease},
volume={199},
pages={106565},
publisher={Elsevier},
year = "2024"
}
A platform for brain network sensing and stimulation with quantitative behavioral tracking: Application to limbic circuit epilepsy.
Kremen V, Sladky V, Mivalt F, Gregg NM, Balzekas I et al. (2024)
Acute to long-term characteristics of impedance recordings during neurostimulation in humans
Cui J, Mivalt F, Sladky V, Kim J, Richner TJ et al. (2024), Journal of Neural Engineering, 21(2)
BibTeX
@article{acutetolongterm-2024/4,
title={Acute to long-term characteristics of impedance recordings during neurostimulation in humans},
author={Cui J, Mivalt F, Sladky V, Kim J, Richner TJ et al.},
journal={Journal of Neural Engineering},
volume={21},
number={026022},
publisher={IOP Publishing},
year = "2024"
}
Pre-existing oscillatory activity as a condition for sub-harmonic entrainment of finely tuned gamma in Parkinson's disease
Sermon J, Starr PA, Denison T & Duchet B (2024), Brain Stimulation, 17(2), 488-490
BibTeX
@article{preexistingosci-2024/4,
title={Pre-existing oscillatory activity as a condition for sub-harmonic entrainment of finely tuned gamma in Parkinson's disease},
author={Sermon J, Starr PA, Denison T & Duchet B},
journal={Brain Stimulation},
volume={17},
pages={488-490},
publisher={Elsevier},
year = "2024"
}
Definition of Implanted Neurological Device Abandonment: A Systematic Review and Consensus Statement.
Okun MS, Marjenin T, Ekanayake J, Gilbert F, Doherty SP et al. (2024), JAMA network open, 7(4), e248654-e248654
BibTeX
@article{definitionofimp-2024/4,
title={Definition of Implanted Neurological Device Abandonment: A Systematic Review and Consensus Statement.},
author={Okun MS, Marjenin T, Ekanayake J, Gilbert F, Doherty SP et al.},
journal={JAMA network open},
volume={7},
pages={e248654-e248654},
year = "2024"
}
Multi-night cortico-basal recordings reveal mechanisms of NREM slow-wave suppression and spontaneous awakenings in Parkinson's disease
Anjum MF, Smyth C, Zuzuárregui R, Dijk DJ, Starr PA et al. (2024), Nature Communications, 15(1)
BibTeX
@article{multinightcorti-2024/2,
title={Multi-night cortico-basal recordings reveal mechanisms of NREM slow-wave suppression and spontaneous awakenings in Parkinson's disease},
author={Anjum MF, Smyth C, Zuzuárregui R, Dijk DJ, Starr PA et al.},
journal={Nature Communications},
volume={15},
number={1793},
publisher={Springer Nature},
year = "2024"
}
Cortical signatures of sleep are altered following effective deep brain stimulation for depression
van Rheede JJ, Alagapan S, Denison TJ, Riva-Posse P, Rozell CJ et al. (2024), Translational Psychiatry, 14(1)
BibTeX
@article{corticalsignatu-2024/2,
title={Cortical signatures of sleep are altered following effective deep brain stimulation for depression},
author={van Rheede JJ, Alagapan S, Denison TJ, Riva-Posse P, Rozell CJ et al.},
journal={Translational Psychiatry},
volume={14},
number={103},
publisher={Springer Nature},
year = "2024"
}
1:2 entrainment is not a device-induced artefact, except when it is
Sermon J, Benjaber M, Duchet B, Anso J, Olaru M et al. (2024), Brain Stimulation, 17(2), 149-151
Acute to long-term characteristics of impedance recordings during neurostimulation in humans
Cui J, Mivalt F, Sladky V, Kim J, Richner TJ et al. (2024)
Bioelectronic Zeitgebers: targeted neuromodulation to re-establish circadian rhythms.
Deli A, Zamora M, Fleming JE, Divanbeighi Zand A, Benjaber M et al. (2024), Conference proceedings. IEEE International Conference on Systems, Man, and Cybernetics, 2023, 2301-2308
BibTeX
@article{bioelectronicze-2024/1,
title={Bioelectronic Zeitgebers: targeted neuromodulation to re-establish circadian rhythms.},
author={Deli A, Zamora M, Fleming JE, Divanbeighi Zand A, Benjaber M et al.},
journal={Conference proceedings. IEEE International Conference on Systems, Man, and Cybernetics},
volume={2023},
pages={2301-2308},
publisher={Institute of Electrical and Electronics Engineers (IEEE)},
year = "2024"
}
MorpheusNet: Resource efficient sleep stage classifier for embedded on-line systems
Kavoosi A, Mitchell MP, Kariyawasam R, Fleming JE, Lewis P et al. (2024)
Prediction of pathological subthalamic nucleus beta burst occurrence in Parkinson’s disease
Abdi-Sargezeh B, Shirani S, Sharma A, Green A, Akram H et al. (2024)
An embedded intracranial seizure monitor for objective outcome measurements and rhythm identification
Fleming J, Benjaber M, Toth R, Zamora M, Landin K et al. (2023), Proceedings of the 45th Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC 2023), 1-6
BibTeX
@inproceedings{anembeddedintra-2023/12,
title={An embedded intracranial seizure monitor for objective outcome measurements and rhythm identification},
author={Fleming J, Benjaber M, Toth R, Zamora M, Landin K et al.},
booktitle={45th Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC 2023)},
pages={1-6},
year = "2023"
}
From dawn till dusk: time-adaptive bayesian optimization for neurostimulation
Fleming JE, Pont Sanchis I, Lemmens O, Denison-Smith A, West TO et al. (2023), PLoS Computational Biology, 19(12)
BibTeX
@article{fromdawntilldus-2023/12,
title={From dawn till dusk: time-adaptive bayesian optimization for neurostimulation},
author={Fleming JE, Pont Sanchis I, Lemmens O, Denison-Smith A, West TO et al.},
journal={PLoS Computational Biology},
volume={19},
number={e1011674},
publisher={Public Library of Science},
year = "2023"
}
MorpheusNet: Resource efficient sleep stage classifier for embedded on-line systems.
Kavoosi A, Mitchell MP, Kariyawasam R, Fleming JE, Lewis P et al. (2023), Conference proceedings. IEEE International Conference on Systems, Man, and Cybernetics, 2023, 2315-2320
BibTeX
@article{morpheusnetreso-2023/10,
title={MorpheusNet: Resource efficient sleep stage classifier for embedded on-line systems.},
author={Kavoosi A, Mitchell MP, Kariyawasam R, Fleming JE, Lewis P et al.},
journal={Conference proceedings. IEEE International Conference on Systems, Man, and Cybernetics},
volume={2023},
pages={2315-2320},
year = "2023"
}
Adaptive Deep Brain Stimulation for sleep stage targeting in Parkinson's disease.
Smyth C, Anjum MF, Ravi S, Denison T, Starr P et al. (2023), Brain stimulation, 16(5), 1292-1296