Biography
Brian completed his BSc in Chemistry (Hons) at the National University of Ireland Galway. He then spent two years working as a Synthetic Chemist for an early stage R+D pharmaceutical company synthesising novel oncology drugs in Sydney, Australia.
He then undertook his PhD studies at the University of Sydney with Prof Roger Truscott where his research focused on the age-related changes that occur in long-lived human proteins and the implications these have for Alzheimer’s disease and multiple sclerosis.
As a postdoctoral researcher within the Davis group (Chemistry, University of Oxford) he worked on a variety of projects all of which were based on modifying viruses, proteins sugars and antibodies to understand, exploit and modify biomolecular function.
While working with Prof Len Seymour (Oncology, University of Oxford) he began applying these skills in a more translational manner to chemically modify oncolytic viruses in order to increase tumour penetration via ultrasound mediated propulsion.
Now as Senior Research Fellow working in the BUBBL group he is primarily developing novel immune stimulating cavitation agents to enhance the potency and tumour specific targeting of cancer immunotherapies.
Most Recent Publications
Bi- and tri-valent T cell engagers deplete tumour-associated macrophages in cancer patient samples
Scott E, Jacobus E & Seymour L (2019), Journal for ImmunoTherapy of Cancer, 7
Monitoring the disassembly of virus-like particles by (19)F-NMR
Leung RL, Robinson MDM, Ajabali AAA, Karunanithy G, Lyons B et al. (2017), Journal of the American Chemical Society, 139(15), 5277-5280
Spontaneous cleavage of proteins at serine and threonine is facilitated by zinc
Lyons B, Kwan AH & Truscott RJW (2016), Aging Cell, 15(2), 237-244
Amyloid Plaque in the Human Brain Can Decompose from Aβ(1-40/1-42) by Spontaneous Nonenzymatic Processes
Lyons B, Friedrich M, Raftery M & Truscott R (2016), Analytical Chemistry, 88(5), 2675-2684
Dysregulation of inter-photoreceptor retinoid-binding protein (IRBP) after induced Müller cell disruption
Zhu L, Shen W, Lyons B, Wang Y, Zhou F et al. (2015), Journal of Neurochemistry, 133(6), 909-918
Research Interests
- Design, formulation and characterisation of immune stimulating cavitation nuclei
- Transdermal delivery of drugs and vaccines
- Synthesis of immune modulating nanoparticles and vaccine formulations
- Developing tumour specific targeting strategies for cancer immunotherapies
Research Funding received from:
- OXCD3
- TherOximmune
- John Fell Research Fund
- Cancer Research Development Fund
Research Groups
Related Academics
Most Recent Publications
Bi- and tri-valent T cell engagers deplete tumour-associated macrophages in cancer patient samples
Scott E, Jacobus E & Seymour L (2019), Journal for ImmunoTherapy of Cancer, 7
Monitoring the disassembly of virus-like particles by (19)F-NMR
Leung RL, Robinson MDM, Ajabali AAA, Karunanithy G, Lyons B et al. (2017), Journal of the American Chemical Society, 139(15), 5277-5280
Spontaneous cleavage of proteins at serine and threonine is facilitated by zinc
Lyons B, Kwan AH & Truscott RJW (2016), Aging Cell, 15(2), 237-244
Amyloid Plaque in the Human Brain Can Decompose from Aβ(1-40/1-42) by Spontaneous Nonenzymatic Processes
Lyons B, Friedrich M, Raftery M & Truscott R (2016), Analytical Chemistry, 88(5), 2675-2684
Dysregulation of inter-photoreceptor retinoid-binding protein (IRBP) after induced Müller cell disruption
Zhu L, Shen W, Lyons B, Wang Y, Zhou F et al. (2015), Journal of Neurochemistry, 133(6), 909-918
Publications
Most Recent Publications
Bi- and tri-valent T cell engagers deplete tumour-associated macrophages in cancer patient samples
Scott E, Jacobus E & Seymour L (2019), Journal for ImmunoTherapy of Cancer, 7
Monitoring the disassembly of virus-like particles by (19)F-NMR
Leung RL, Robinson MDM, Ajabali AAA, Karunanithy G, Lyons B et al. (2017), Journal of the American Chemical Society, 139(15), 5277-5280
Spontaneous cleavage of proteins at serine and threonine is facilitated by zinc
Lyons B, Kwan AH & Truscott RJW (2016), Aging Cell, 15(2), 237-244
Amyloid Plaque in the Human Brain Can Decompose from Aβ(1-40/1-42) by Spontaneous Nonenzymatic Processes
Lyons B, Friedrich M, Raftery M & Truscott R (2016), Analytical Chemistry, 88(5), 2675-2684
Dysregulation of inter-photoreceptor retinoid-binding protein (IRBP) after induced Müller cell disruption
Zhu L, Shen W, Lyons B, Wang Y, Zhou F et al. (2015), Journal of Neurochemistry, 133(6), 909-918