Michael Gray

Dr. Michael Gray is a Senior Researcher in Clinical Therapeutic Ultrasound. He joined the BUBBL group in September 2015 as the lead engineer on a Phase-1 clinical trial of ultrasound-mediated targeted drug delivery for treatment of liver cancer.

Over the preceding 23 years, he was a research engineer and principal investigator at Georgia Tech, working in research areas including submarine sonar, cetacean soft tissue characterization, photoacoustics, fish hearing, and non-destructive structural evaluation.

Michael's research focuses on three areas:

1. Early phase clinical trials of ultrasound-mediated drug delivery for treatment of abdominal organ cancers
2. Clinical translation of quantitative cavitation monitoring techniques for non-invasive treatment guidance, and
3. Development of devices to enable the use of sound, magnetism, and light for targeted drug delivery.

Fuenteslópez, C.V., Gray, M.D., Bahcevanci, S., Martin, A., Smith, Cameron, Coussios, C., Cui, Z., Ye, H., & Patrulea, V. (2024). Mesenchymal stem cell cryopreservation with cavitation-mediated trehalose treatment. Commun Eng 3(129). DOI

Gray, M.D., Spiers, L., & Coussios, C. (2023). Sound speed and attenuation of human pancreas and pancreatic tumors and their influence on focused ultrasound thermal and mechanical therapies. Medical Physics (in press), DOI

Gray, M.D., Spiers, L., & Coussios, C. (2022). Effects of human tissue acoustic properties, abdominal wall shape, and respiratory motion on ultrasound-mediated hyperthermia for targeted drug delivery to pancreatic tumors. International Journal of Hyperthermia 39(1), 918-934, DOI

Gray, M.D., Elbes, D., Paverd, C., Lyka, E., Coviello, C., Cleveland, R., & Coussios, C. (2021). Dual array passive acoustic mapping for cavitation imaging with enhanced 2-D resolution. IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control 68(3), 647-663, DOI

Beguin, E., Gray, M.D., Logan, K.A., Nesbitt, H., Sheng, Y., Kamila, S., Barnsley, L.C., Bau, L., McHale, A.P., Callan, J.F., & Stride, E. (2020). Magnetic microbubble mediated chemo-sonodynamic therapy using a combined magnetic-acoustic device. Journal of Controlled Release 317, 23-33, DOI

Gray, M.D., Lyon, P.C., Mannaris, C., Folkes, L.K., Stratford, M., Campo, L., Chung, D.Y.F., Scott, S., Anderson, M., Goldin, R., Carlisle, R., Wu, F., Middleton, M.R., Gleeson, F.V., & Coussios, C.C. (2019). Focused Ultrasound Hyperthermia for Targeted Drug Release from Thermosensitive Liposomes: Results from a Phase I Trial. Radiology 291, 232-238, DOI

Gray, M.D. and Coussios, C.C. (2018). Broadband ultrasonic attenuation estimation and compensation with passive acoustic mapping. IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control 65(11), 1997-2011, DOI

Sengupta, A., Gray, M.D., Kelly, S.C., Holguin, S., Thadhani, N., & Prausnitz, M.R. (2017). Energy transfer mechanisms during molecular delivery to cells by laser-activated carbon nanoparticles.  Biophysical Journal 112, 1258-1269, DOI

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