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Dr Michael Gray


Michael Gray

Senior Researcher in Clinical Therapeutic Ultrasound


Dr. Michael Gray is a Senior Researcher in Clinical Therapeutic Ultrasound. He joined the BUBBL group in September 2015 as the lead engineer on a Phase-1 clinical trial of ultrasound-mediated targeted drug delivery for treatment of liver cancer.

Over the preceding 23 years, he was a research engineer and principal investigator at Georgia Tech, working in research areas including submarine sonar, cetacean soft tissue characterization, photoacoustics, fish hearing, and non-destructive structural evaluation.



Research Interests

Michael's research focuses on three areas:

  1. Early phase clinical trials of ultrasound-mediated drug delivery for treatment of abdominal organ cancers
  2. Clinical translation of quantitative cavitation monitoring techniques for non-invasive treatment guidance, and
  3. Development of devices to enable the use of sound, magnetism, and light for targeted drug delivery.

Research Groups

Selected Publications

Gray, M.D., Spiers, L., & Coussios, C. (2022). Effects of human tissue acoustic properties, abdominal wall shape, and respiratory motion on ultrasound-mediated hyperthermia for targeted drug delivery to pancreatic tumors. International Journal of Hyperthermia 39(1), 918-934, DOI

Gray, M.D., Elbes, D., Paverd, C., Lyka, E., Coviello, C., Cleveland, R., & Coussios, C. (2021). Dual array passive acoustic mapping for cavitation imaging with enhanced 2-D resolution. IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control 68(3), 647-663, DOI

Beguin, E., Gray, M.D., Logan, K.A., Nesbitt, H., Sheng, Y., Kamila, S., Barnsley, L.C., Bau, L., McHale, A.P., Callan, J.F., & Stride, E. (2020). Magnetic microbubble mediated chemo-sonodynamic therapy using a combined magnetic-acoustic device. Journal of Controlled Release 317, 23-33, DOI

Gray, M.D., Lyon, P.C., Mannaris, C., Folkes, L.K., Stratford, M., Campo, L., Chung, D.Y.F., Scott, S., Anderson, M., Goldin, R., Carlisle, R., Wu, F., Middleton, M.R., Gleeson, F.V., & Coussios, C.C. (2019). Focused Ultrasound Hyperthermia for Targeted Drug Release from Thermosensitive Liposomes: Results from a Phase I Trial. Radiology 291, 232-238, DOI

Gray, M.D. and Coussios, C.C. (2018). Broadband ultrasonic attenuation estimation and compensation with passive acoustic mapping. IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control 65(11), 1997-2011, DOI

Sengupta, A., Gray, M.D., Kelly, S.C., Holguin, S., Thadhani, N., & Prausnitz, M.R. (2017). Energy transfer mechanisms during molecular delivery to cells by laser-activated carbon nanoparticles.  Biophysical Journal 112, 1258-1269, DOI

Full Listing at Google Scholar