Biography
Stephen was an undergraduate (MEng 1997) and a graduate (DPhil 2001) student in the department.
Following a post-doc and a stint as a Departmental Lecturer, he was appointed to his current post in 2006. In 2018 he was promoted to Full Professor.
Stephen's research interests in cerebral blood flow and metabolism, in particular modelling this highly complex organ and understanding how flow is controlled. His research group is based at the Institute of Biomedical Engineering.
Most Recent Publications
Modelling the impact of clot fragmentation on the microcirculation after thrombectomy
El-Bouri WK et al. (2021), PLoS Computational Biology, 17(3)
Coupling one-dimensional arterial blood flow to three-dimensional tissue perfusion models for in silico trials of acute ischaemic stroke
Jozsa T et al. (2020), Interface Focus, 11(1)
A porous circulation model of the human brain for in silico clinical trials in ischaemic stroke
Jozsa T et al. (2020), Interface Focus
Lung heterogeneity and deadspace volume in acute respiratory distress syndrome animals using the inspired sinewave test
Tran MC et al. (2020), Physiological Measurement, 41(11)
Reliability, reproducibility and validity of dynamic cerebral autoregulation in a large cohort with transient ischaemic attack or minor stroke
Lee Y-K et al. (2020), Physiological Measurement, 41(9)
Research Interests
Stephen's research interests lie in biomedical engineering, in particular cerebral blood flow and metabolism. He is interested in modelling how blood flow and metabolism are coupled and how blood flow is controlled. This is a highly interdisciplinary field, so he works with a wide range of collaborators around the world, both modelling and experimental groups.
Stephen's current research topics involve modelling the interaction between microthrombi and the microvasculature, understanding the physiological nature of autoregulation and exploring how whole brain models of cerebral blood flow can be constructed.
Research Groups
Current Projects
INSIST - Modelling thrombectomy in stroke
Other Research Activities
Stephen is also Chair of the Cerebral Autoregulation Research Network
Most Recent Publications
Modelling the impact of clot fragmentation on the microcirculation after thrombectomy
El-Bouri WK et al. (2021), PLoS Computational Biology, 17(3)
Coupling one-dimensional arterial blood flow to three-dimensional tissue perfusion models for in silico trials of acute ischaemic stroke
Jozsa T et al. (2020), Interface Focus, 11(1)
A porous circulation model of the human brain for in silico clinical trials in ischaemic stroke
Jozsa T et al. (2020), Interface Focus
Lung heterogeneity and deadspace volume in acute respiratory distress syndrome animals using the inspired sinewave test
Tran MC et al. (2020), Physiological Measurement, 41(11)
Reliability, reproducibility and validity of dynamic cerebral autoregulation in a large cohort with transient ischaemic attack or minor stroke
Lee Y-K et al. (2020), Physiological Measurement, 41(9)
Books
Payne, S.J. Cerebral Blood Flow and Metabolism. World Scientific, 2017.
Payne, S.J. Cerebral Autoregulation. Springer, 2016.
Chappell, M.A. and Payne, S.J. Physiology for Engineers. Springer, 2016.
Most Recent Publications
Modelling the impact of clot fragmentation on the microcirculation after thrombectomy
El-Bouri WK et al. (2021), PLoS Computational Biology, 17(3)
Coupling one-dimensional arterial blood flow to three-dimensional tissue perfusion models for in silico trials of acute ischaemic stroke
Jozsa T et al. (2020), Interface Focus, 11(1)
A porous circulation model of the human brain for in silico clinical trials in ischaemic stroke
Jozsa T et al. (2020), Interface Focus
Lung heterogeneity and deadspace volume in acute respiratory distress syndrome animals using the inspired sinewave test
Tran MC et al. (2020), Physiological Measurement, 41(11)
Reliability, reproducibility and validity of dynamic cerebral autoregulation in a large cohort with transient ischaemic attack or minor stroke
Lee Y-K et al. (2020), Physiological Measurement, 41(9)
DPhil Opportunities
I aim to take 2-3 DPhil students each year. Projects will be in the broad area of cerebral blood flow and metabolism.
Most Recent Publications
Modelling the impact of clot fragmentation on the microcirculation after thrombectomy
El-Bouri WK et al. (2021), PLoS Computational Biology, 17(3)
Coupling one-dimensional arterial blood flow to three-dimensional tissue perfusion models for in silico trials of acute ischaemic stroke
Jozsa T et al. (2020), Interface Focus, 11(1)
A porous circulation model of the human brain for in silico clinical trials in ischaemic stroke
Jozsa T et al. (2020), Interface Focus
Lung heterogeneity and deadspace volume in acute respiratory distress syndrome animals using the inspired sinewave test
Tran MC et al. (2020), Physiological Measurement, 41(11)
Reliability, reproducibility and validity of dynamic cerebral autoregulation in a large cohort with transient ischaemic attack or minor stroke
Lee Y-K et al. (2020), Physiological Measurement, 41(9)
