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Zhanfeng Cui Professor of Chemical Engineering, Oxford University

Professor

Zhanfeng Cui PhD, DSc, FIChemE, FAIMBE, FREng, FMedSci

Donald Pollock Professor of Chemical Engineering

Founding Director, Oxford Suzhou Centre for Advanced Research (OSCAR)

Professorial Fellow, Hertford College

TEL: 01865 617693
COLLEGE: Hertford College

Career

2000-Present: Donald Pollock Professor of Chemical Engineering, Oxford University

2000-Present: Professorial Fellow of Hertford College, Oxford

2001-2020 – Founding Director, Oxford Centre for Tissue Engineering and Bioprocessing

2005-2010 – Changjiang Visiting Professor, Dalian University of Technology, China

2004 – Braun Intertec Visiting Professor, University of Minnesota, USA

Oct 1999 – 2000: Reader in Engineering Science, Oxford University

Jan 1999 - Sep 1999 – Visiting Professor, Georgia Institute of Technology, USA

Oct 1994 – Sep 2000: Official Fellow and Engineering Tutor, Keble College, Oxford

Oct 1994 – Sep 1999: University Lecturer in Engineering Science, Oxford University

Apr 1991 – Sep 1994: Lecturer, Department of Chemical Engineering, University of Edinburgh, UK

May 1990 – Mar 1991: Research Fellow, Department of Pharmacy, University of Strathclyde, UK

Oct 1988 – Apr 1990: Research Associate, Bioengineering Unit, University of Strathclyde, UK

Education and Qualifications

Oct 1978 – Jul 1982 : BSc in Chemical Engineering,1982, Inner Mongolia Polytechnic University (China)

Sep 1982 – Dec 1985: MSc in Chemical Engineering, 1984, Dalian University of Technology (China)

Jan 1986 – Dec 1988:  PhD in Chemical Engineering,1987, Dalian University of Technology (China)

MA, 1994, Keble College, Oxford

DSc, 2009, University of Oxford

CSci, 2004, The Science Council, UK

CEng, 1997, The Engineering Council, UK

Fellow, Institution of the Chemical Engineers (FIChemE), 2003

Fellow, American Institute for Medical and Biological Engineering, 2014

Other Roles

Editor-in-Chief: Bio-Design and Manufacturing

Trustee: Oxford China Scholarship Fund (COSF)

Research Interests

Regenerative Medical Engineering and Technologies

Bioreactor technology for tissue culture and stem cell expansion;  Cryopreservation of stem cells and engineered tissue;  Stem cell therapy for neural degeneration and repair.

Biomanufacture,  Bioprocessing,  and Bioformulation

Synthetic biology approach for biomanufacturing; Intelligent manufacturing of new therapeutics, 3D bioprinting, Bioproduct separation and formulations.

Medical devices for detecting infectious diseases including Covid-19 and cancer

Molecular diagnostics using  the OxLAMP®  technology for   infectious diseases;  Home screening and POC testing for early detection of cancers.

Recognition and Awards

Fellow, The Royal Academy of Engineering, 2013

International Member, Chinese Academy of Engineering, 2021

Fellow, Academy of Medical Sciences, 2023

 

Overall Achievement Award, The 2023 IChemE Global Award, 2023

Best Start-up Award,  The 2023 IChemE Global Award, 2023

Innovative Product Award, The 2023 IChemE Global Award, 2023

President’s Special Award, The Royal Academy of Engineering, 2020

The 2010 Basil Brennan Medal, IChemE, 2011

 

Distinguished Visiting Professor, Tsinghua University, China (2023-2025)

Distinguished Visiting Professor, City University of Hong Kong (2024-2026)

Recent Publications

  1. Lim B, Yin Y, Ye H, Cui Z, Papachristodoulou A, Huang WE. Reprogramming Synthetic Cells for Targeted Cancer Therapy. ACS Synth Biol. 2022 Mar 18;11(3):1349-1360. https://doi: 10.1021/acssynbio.1c00631
  2. Martin, R.; Lei, R.; Zeng, Y.; Zhu, J.; Chang, H.; Ye, H.; Cui, Z. Membrane Applications in Autologous Cell Therapy. Membranes 2022, 12, 1182. https://doi.org/10.3390/membranes12121182
  3. Yu, Y., Zhou, J.X.Y., Li, B., Ji, M., Wang, Y., Carnaby, E. et al. (2022) A quantitative RT-qLAMP for the detection of SARS-CoV-2 and human gene in clinical application. Microbial Biotechnology, 2022, 15 (10): 2619-2630. Available from: https://doi.org/10.1111/1751-7915.14112.
  4. Nguyen, L. T. B., Baudequin, T., Cui, Z., & Ye, H. (2022) Validation and scalability of homemade polycaprolactone macrobeads grafted with thermo-responsive poly(N-isopropylacrylamide) for mesenchymal stem cell expansion and harvesting. Biotechnology and Bioengineering, 119, 2345– 2358. https://doi.org/10.1002/bit.28133
  5. Lam C, Meinert E, Yang A, Cui Z. (2022) Impact of fast-track regulatory designations on strategic commercialization decisions for autologous cell therapies. Regen Med. 17(3):155-174. https://doi: 10.2217/rme-2021-0061.
  6. Hsu, C.C., Julian H George, Sharlayne Waller, Cyril Besnard, David A Nagel, Eric J Hill, Michael D Coleman, Alexander M Korsunsky, Zhanfeng Cui, Hua Ye (2022), Increased connectivity of hiPSC-derived neural networks in multiphase granular hydrogel scaffolds, Bioreactive Materials, 9:358-372, published online on 15/7/2021. doi:10.1016/j.bioactmat.2021.07.008.
  7. Lim, B., Jeremy Ratcliff, Dorota A Nawrot, Yejiong Yu, Harshmeena R Sanghani, Chia-Chen Hsu, Leon Peto, Simon Evans, Susanne H Hodgson, Aikaterini Skeva, Maria Adam, Maria Panopoulou, Christos E Zois, Katy Poncin, Sridhar R Vasudevan, Siqi Dai, Shuai Ren, Hong Chang, Zhanfeng Cui, Peter Simmonds, Wei E Huang, Monique I Andersson (2021), Clinical validation of optimised RT-LAMP for the diagnosis of SARS-CoV-2 infection, Sci Rep 11: 1-11. doi:10.1038/s41598-021-95607-1.
  8. Hsu, C C, Xu, J, Bas, B, Wang, H, Cui, Z F,Huang, W, Ye, H (2020), A single-cell Raman-based platform to identify developmental stages of human pluripotent stem cells-derived neurons, PNAS, 117 (31) 18412-18423. doi:10.1073/pnas.2001906117
  9. Lam, C, E. Meinert, A. Yang, Z. Cui (2021), Comparison between centralized and decentralized supply chains of autologous chimeric antigen receptor T-cell therapies: a UK case study based on discrete event simulation, Cytotherapy, 23(5):433-451. Available online 2 Mar 2021. doi:10.1016/j.jcyt.2020.08.007
  10. George, J., Hsu, C.C., Nguyen, L.T.B., Ye, H. and Cui, Z. (2020). Neural tissue engineering with structured hydrogels in CNS models and therapies. Biotechnology Advances. 42: 107370 doi: 10.1016/j.biotechadv.2019.03.009.
  11. Tayebi, L., Cui, Z. & Ye, H (2020). A tri-component knee plug for the 3rd generation of autologous chondrocyte implantation. Sci Rep 10, 17048. doi:10.1038/s41598-020-73863-x
  12. Cui Z, Chang H, Wang H, Lim B, Hsu CC, Yu Y, Jia H, Wang Y, Zeng Y, Ji M, Liu W (2020), Inverarity C, Huang WE. Development of a rapid test kit for SARS-CoV-2: an example of product design. Biodes Manuf. 11:1-4. doi: 10.1007/s42242-020-00075-7.
  13. Huang WE, Lim B, Hsu CC, Xiong D, Wu W, Yu Y, Jia H, Wang Y, Zeng Y, Ji M, Chang H, Zhang X, Wang H, Cui Z (2020). RT-LAMP for rapid diagnosis of coronavirus SARS-CoV-2. Microb Biotechnol. 13(4):950-961. doi: 10.1111/1751-7915.13586. (Wiley Top Downloaded Article in 2021)
  14. Fan, C, Davison, P A, Habgood, R, Zeng, H, Decker, C M, Salazar, M G, Lueangwattanapong, K, Townley, H E, Yang, A, Thompson, I P, Ye, H, Cui Z F, Schmidt, F, Hunter, C N, Huang, W E (2020), Chromosome-free bacterial cells are safe and programmable platforms for synthetic biology PNAS, 117 (12) 6752-6761. doi:10.1073/pnas.1918859117