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A portrait of Researcher, Jonathan Hedley

Dr

Jonathan Hedley PhD

Novo Nordisk Postdoctoral Research Fellow

Biography

Jonathan Hedley is a Novo Nordisk Postdoctoral Research Fellow in the lab of Prof. Philip Torr at Oxford University. His research focuses on adapting deep multi-modal generative models, typically used in text and image processing, to genomic data. The ultimate goal is to develop foundational and causal deep-phenotypic cellular models for reliably predicting cellular responses to genetic perturbations. These advancements are crucial for identifying new drug targets and guiding the exploration of genetic perturbations to uncover new biological insights.

He graduated with a first-class MSci degree in Chemistry with Molecular Physics from Imperial College London in 2020, where he received awards for Overall Outstanding Achievement and excellence in Computational Chemistry. His master's research explored mechanisms for sequence recognition in chromatin, specifically how sequence-specific nucleosome positioning may facilitate homologous recombination. After being awarded the President's PhD Scholarship at Imperial, he defended his PhD in Chemical Physics in 2024. His doctoral research examined how structured water influences the electrostatic environment surrounding dsDNA and enhances sequence recognition between homologous dsDNA molecules. This work also contributed to a new understanding of the role of water within the electrochemical double layer.

Research Interests

  • AI for Drug Discovery
  • Soft Condensed Matter Physics
  • Electrochemistry
  • Statistical Physics

Research Projects

Navigating the genetic perturbation landscape: Multi-modal causal representation learning for target discovery. Summary: Using multi-modal machine learning to predict cellular responses to genetic perturbations.

Related Academics

Publications

Water structural effects on DNA???DNA interactions and homologous recognition

Hedley JG, Haimov E & Kornyshev AA (2024), Physica A: Statistical Mechanics and its Applications, 647, 129894-129894

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BibTeX View PDF
@article{waterstructural-2024/8,
  title={Water structural effects on DNA???DNA interactions and homologous recognition},
  author={Hedley JG, Haimov E & Kornyshev AA},
  journal={Physica A: Statistical Mechanics and its Applications},
  volume={647},
  number={129894},
  pages={129894-129894},
  publisher={Elsevier BV},
  year = "2024"
}

Nonlocal structural effects of water on DNA homology recognition.

Haimov E, Hedley JG & Kornyshev AA (2024), Journal of physics. Condensed matter : an Institute of Physics journal, 36(40)

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BibTeX View PDF
@article{nonlocalstructu-2024/7,
  title={Nonlocal structural effects of water on DNA homology recognition.},
  author={Haimov E, Hedley JG & Kornyshev AA},
  journal={Journal of physics. Condensed matter : an Institute of Physics journal},
  volume={36},
  year = "2024"
}

Nonlocal Structural Effects of Water on DNA Homology Recognition

Haimov E, Hedley JG & Kornyshev AA (2024)

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BibTeX
@misc{nonlocalstructu-2024/2,
  title={Nonlocal Structural Effects of Water on DNA Homology Recognition},
  author={Haimov E, Hedley JG & Kornyshev AA},
  year = "2024"
}

The Dramatic Effect of Water Structure on Hydration Forces and the Electrical Double Layer

Hedley JG, Berthoumieux H & Kornyshev AA (2023), The Journal of Physical Chemistry C, 127(18), 8429-8447

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@article{thedramaticeffe-2023/5,
  title={The Dramatic Effect of Water Structure on Hydration Forces and the Electrical Double Layer},
  author={Hedley JG, Berthoumieux H & Kornyshev AA},
  journal={The Journal of Physical Chemistry C},
  volume={127},
  pages={8429-8447},
  publisher={American Chemical Society (ACS)},
  year = "2023"
}

Nucleosome-induced homology recognition in chromatin.

Hedley JG, Teif VB & Kornyshev AA (2021), Journal of the Royal Society, Interface, 18(179), 20210147

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@article{nucleosomeinduc-2021/6,
  title={Nucleosome-induced homology recognition in chromatin.},
  author={Hedley JG, Teif VB & Kornyshev AA},
  journal={Journal of the Royal Society, Interface},
  volume={18},
  pages={20210147},
  year = "2021"
}

Nucleosome induced homology recognition in chromatin

Hedley JG, Teif VB & Kornyshev AA (2021)

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BibTeX View PDF
@misc{nucleosomeinduc-2021/4,
  title={Nucleosome induced homology recognition in chromatin},
  author={Hedley JG, Teif VB & Kornyshev AA},
  year = "2021"
}

Electric Field of DNA in Solution: Who Is in Charge?

Hedley JG, Coshic K, Aksimentiev A & Kornyshev AA (0), Physical Review X, 14(3)

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BibTeX View PDF
@article{electricfieldof-/,
  title={Electric Field of DNA in Solution: Who Is in Charge?},
  author={Hedley JG, Coshic K, Aksimentiev A & Kornyshev AA},
  journal={Physical Review X},
  volume={14},
  number={031042},
  publisher={American Physical Society (APS)}
}